Chloride → tert-Butyl 4-bromo-2-fluorobenzoate

HRID 203072Notes

Reaction equation

HRID 203072 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:11])[c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10]1.[C:19]([CH3:20])([CH3:21])([CH3:22])[OH:23].[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[Cl-:18].[Cl:12][C:13]([C:14]([Cl:15])=[O:16])=[O:17].[Cl:29][CH2:30][Cl:31].[O:38]=[CH:39][N:40]([CH3:41])[CH3:42].[cH:32]1[cH:33][cH:34][n:35][cH:36][cH:37]1>>[Br:1][c:2]1[cH:3][c:4]([F:11])[c:5]([C:6](=[O:7])[O:8][C:19]([CH3:20])([CH3:21])[CH3:22])[cH:9][cH:10]1

Participants

9

Reactant 8

HCID 312ChlorideHCID 1049PyridineHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 6386tert-ButanolHCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 3026814-Bromo-2-fluorobenzoic acid

Product 1

HCID 46738774tert-Butyl 4-bromo-2-fluorobenzoate

Sources & evidence

ORD record
ord-5b27e7ae890447ff83f4205c7f2b4ccc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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