Water → N-[3,5-bis(trifluoromethyl)benzyl]-2-chloro-N-(3-hydroxypropyl)-4-iodonicotinamide
Reaction equation
[CH3:16][N:17]([CH3:18])[CH:19]=[O:20].[CH3:47][CH2:48][N:49]([CH2:50][CH3:51])[CH2:52][CH3:53].[Cl:5][c:6]1[c:7]([C:8](=[O:9])[OH:10])[c:11]([I:15])[cH:12][cH:13][n:14]1.[F:21][C:22]([c:23]1[cH:24][c:25]([CH2:26][NH:27][CH2:28][CH2:29][CH2:30][OH:31])[cH:32][c:33]([C:35]([F:36])([F:37])[F:38])[cH:34]1)([F:39])[F:40].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1.[OH2:46].[S:1]([Cl:2])([Cl:3])=[O:4]>>[Cl:5][c:6]1[c:7]([C:8](=[O:10])[N:27]([CH2:26][c:25]2[cH:24][c:23]([C:22]([F:21])([F:39])[F:40])[cH:34][c:33]([C:35]([F:36])([F:37])[F:38])[cH:32]2)[CH2:28][CH2:29][CH2:30][OH:31])[c:11]([I:15])[cH:12][cH:13][n:14]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-2bff8d4b101c4106ab9ce431f733f15b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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