2,2,2-Trifluoroethanol → HCID 11469181, compound

HRID 2049824Notes

Reaction equation

HRID 2049824 reaction equation
[F:1][C:2]([F:6])([F:5])[CH2:3][OH:4].Cl[CH2:8][C:9]([CH3:11])=[CH2:10].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:10][C:9](=[CH2:8])[CH2:11][O:4][CH2:3][C:2]([F:6])([F:5])[F:1]

Participants

5

Reactant 3

HCID 64092,2,2-TrifluoroethanolHCID 112413-Chloro-2-methyl-1-propeneHCID 11430Potassium Carbonate

Product 1

HCID 11469181HCID 11469181, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In 100 ml DMF is placed 2,2,2-trifluoroethanol (20 g), 3-chloro-2-methyl-1-propene (18.1 g) and potassium carbonate (33.15 g). The mixture is heated to 50°, with stirring, for 15 hr. The solution is cooled and extracted with pentane. The pentane layer is washed with water (3X) and dried over sodium sulfate. The pentane is fractionally distilled off and the product is distilled in vacuo to give 2,2,2-trifluoroethyl 2-methyl-2-propenyl ether.

Workup

  1. temperatureThe mixture is heated to 50°
  2. temperatureThe solution is cooled
  3. extractionextracted with pentane
  4. washThe pentane layer is washed with water (3X)
  5. dry with materialdried over sodium sulfate
  6. distillationThe pentane is fractionally distilled off
  7. distillationthe product is distilled in vacuo

Sources & evidence

ORD record
ord-d0fa6fe5fd1e4e2a863661f6ed025f36
Source dataset
uspto-grants-1980_04
Patent number
US04198527

Reaction notes

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