Potassium Carbonate → HCID 69224673, compound

HRID 2052814Notes

Reaction equation

HRID 2052814 reaction equation
Br[CH:2]([CH3:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[ClH:12].[OH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][C:21]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)=[O:22].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:12].[C:3]([CH:2]([N:26]1[CH2:25][CH2:24][N:23]([C:21](=[O:22])[CH2:20][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[OH:13])[CH2:28][CH2:27]1)[CH3:11])(=[O:4])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 164522-BromopropiophenoneHCID 68809102HCID 68809102, compound

Product 1

HCID 69224673HCID 69224673, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-bromo-1-phenylpropan-1-one (3 mmol), N-(2-hydroxy-phenyl acetyl)piperazine hydrochloride (2.5 mmol) and K2CO3 (8.75 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-18), 0.65 g (67%), M+ 353.

Workup

  1. additionwas treated
  2. customaccording to the general preparation 2
  3. customto give compound (IV-18), 0.65 g (67%), M+ 353

Sources & evidence

ORD record
ord-37dc5b85e5034c63a36743aded7ba5c3
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

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