Triethylamine → HCID 178470444, compound

HRID 2053950Notes

Reaction equation

HRID 2053950 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10]2[CH2:11][CH2:12][CH2:13][C:9]=2[N:8]([C:14]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=O)=[CH:16][C:15]=2[C:23]([F:26])([F:25])[F:24])[N:7]=1)=[O:5])[CH3:2].C[N:28](C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(CC)CC)C.[Cl:56][C:57]1[CH:68]=[CH:67][C:60]2[NH:61][C:62]([CH2:64][CH2:65]N)=[N:63][C:59]=2[CH:58]=1>O1CCCC1.C(OCC)(=O)C>[Cl:56][C:57]1[CH:68]=[CH:67][C:60]2[NH:61][C:62]([CH:64]([NH:28][C:18](=[O:20])[C:17]3[CH:21]=[CH:22][C:14]([N:8]4[C:9]5[CH2:13][CH2:12][CH2:11][C:10]=5[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[N:7]4)=[C:15]([C:23]([F:24])([F:25])[F:26])[CH:16]=3)[CH3:65])=[N:63][C:59]=2[CH:58]=1

Participants

7

Reactant 4

HCID 8471TriethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 69314856HCID 69314856, compoundHCID 178510880HCID 178510880, compound

Product 1

HCID 178470444HCID 178470444, compoundYield 52%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

Prepared analogously to Example 1g from 4-[3-(ethoxycarbonyl)-5,6-dihydro-4H-cyclopentapyrazol-1-yl]-3-trifluoromethylbenzoic acid, TBTU, triethylamine, and (5-chloro-1H-benzimidazol-2-yl)ethylamine in tetrahydrofuran. Yield: 52%; Rf value: 0.40 (silica gel; ethyl acetate);C26H23ClF3N5O3 (545.95); mass spectrum: (M+H)+=546.

Sources & evidence

ORD record
ord-ed569dd216eb45c8b579cdb802e6aa7f
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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