4-Nitrobenzaldehyde → HCID 15722298, compound

HRID 2059359Notes

Reaction equation

HRID 2059359 reaction equation
O=Cc1ccc([N+](=O)[O-])cc1.CCSC(=O)CC(=O)O>C1CCNC1.CN(C)c1ccncc1.C1CCOC1>CCSC(=O)/C=C/c1ccc([N+](=O)[O-])cc1

Participants

6

Reactant 2

HCID 5414-NitrobenzaldehydeHCID 127870873-Ethylsulfanyl-3-oxopropanoic acid

Product 1

HCID 15722298HCID 15722298, compoundYield 71%

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineReagentHCID 31268PyrrolidineCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
25 °C

Workup

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Keep Organic
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Sources & evidence

ORD record
ord-16f0e6904fb14454b246bf010483cd0a
Source dataset
Transfer learning optimization of 26 decarboxylative olefination reactions

Reaction notes

Loading…