Dimethylformamide → 3-(1-cyanocyclobutyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide

HRID 206093Notes

Reaction equation

HRID 206093 reaction equation
[C:1](#[N:2])[C:3]1([c:7]2[cH:8][c:9]([C:10](=[O:11])[OH:12])[cH:13][cH:14][cH:15]2)[CH2:4][CH2:5][CH2:6]1.[CH3:22][N:23]([CH3:24])[CH:25]=[O:26].[CH3:50][N:51]1[CH2:52][CH2:53][CH2:54][C:55]1=[O:56].[Cl:16][C:17]([C:18]([Cl:19])=[O:20])=[O:21].[NH2:27][c:28]1[cH:29][c:30]([O:31][c:32]2[cH:33][cH:34][c:35]3[n:36]([n:37]2)[cH:38][c:39]([NH:41][C:42](=[O:43])[CH:44]2[CH2:45][CH2:46]2)[n:40]3)[cH:47][cH:48][cH:49]1.[O:57]1[CH2:58][CH2:59][CH2:60][CH2:61]1>>[C:1](#[N:2])[C:3]1([c:7]2[cH:8][c:9]([C:10](=[O:12])[NH:27][c:28]3[cH:29][c:30]([O:31][c:32]4[cH:33][cH:34][c:35]5[n:36]([n:37]4)[cH:38][c:39]([NH:41][C:42](=[O:43])[CH:44]4[CH2:45][CH2:46]4)[n:40]5)[cH:47][cH:48][cH:49]3)[cH:13][cH:14][cH:15]2)[CH2:4][CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 13387N-methyl-2-pyrrolidoneHCID 65578Oxalyl chlorideHCID 57386059N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamideHCID 574410433-(1-Cyanocyclobutyl)benzoic acid

Product 1

HCID 575057003-(1-cyanocyclobutyl)-N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]benzamide

Sources & evidence

ORD record
ord-627e886cffa54d058e01c1335365e804
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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