反应详情

1-(3-Hydroxyphenyl)piperazine (200 mg) was dissolved in tetrahydrofuran (10 ml), the solution was added with saturated aqueous sodium hydrogencarbonate (10 ml) and benzyl chloroformate (176 μl) at room temperature, and the mixture was stirred for 14 hours. The reaction mixture was added with ethyl acetate for extraction, and the organic layer was dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1) to obtain the title compound (342 mg).

1. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
2. filtrationfiltered
3. concentrationThe filtrate was concentrated under reduced pressure
4. customthe resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1)