反应详情

To the solution of sodium salt of di-protected Ertapenem (50 g) {prepared by following the process disclosed in WO 2008062279} in a mixture of carbonated water (500 ml), IPA (2.6 ml) and ethyl acetate (20 L) in autoclave were charged sodium bicarbonate (6.5 gm) and Pd/carbon and subjected to hydrogenation with 3 to 10 Kg pressure at 5-10° C. After completion of reaction CO2 gas was purged and the reaction mass was filtered. The aqueous layer was separated, washed with ethyl acetate and was treated with activated carbon and neutral alumina, the residual solvents in aqueous layer removed using degassing technique and filtered. The aqueous layer was filtered through 0.2 micron filter paper and added into isopropyl alcohol and ethanol under stirring. The precipitated amorphous form of Ertapenem disodium (having moisture content: about 7% to 11%) was slurry washed with ethanol and IPE. The obtained solid (having moisture content: about 2.5% to 6%) was dried using dry N2 gas followed by humidified N2 gas to yield amorphous form of Ertapenem disodium (having moisture content: about 7% to 12%) and again dried using dry N2 gas at about 5-10° C. to yield amorphous form of Ertapenem disodium having moisture content (2.5-4.5%) with pharmaceutically acceptable level of residual solvent.

1. customsubjected to hydrogenation with 3 to 10 Kg pressure at 5-10° C
2. customwas purged
3. filtrationthe reaction mass was filtered
4. customThe aqueous layer was separated
5. washwashed with ethyl acetate
6. additionwas treated with activated carbon and neutral alumina
7. customthe residual solvents in aqueous layer removed
8. customusing degassing technique
9. filtrationfiltered
10. filtrationThe aqueous layer was filtered through 0.2 micron
11. filtrationfilter paper
12. additionadded into isopropyl alcohol and ethanol
13. washwashed with ethanol and IPE
14. customThe obtained solid (having moisture content: about 2.5% to 6%) was dried