4-Chlorophenol → 2-(4-Chlorophenoxy)propan-1-ol

HRID 2072321Notes

Reaction equation

HRID 2072321 reaction equation
[Na].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.Br[CH:11]([CH3:14])[CH2:12][OH:13]>C(O)(C)C>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH:11]([CH3:14])[CH2:12][OH:13])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 46844-ChlorophenolHCID 117132-Bromopropan-1-olHCID 5360545Sodium

Product 1

HCID 132594172-(4-Chlorophenoxy)propan-1-ol

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2.3 g. of sodium are dissolved in 170 ml. of absolute isopropanol, 12.85 g. of p-chlorophenol are introduced, 13.9 g. of 2-bromo-propanol are added dropwise and the mixture is boiled for 20 hours. The mixture is evaporated and worked up using water and ether to give 2-(4-chlorophenoxy)-propanol.

Workup

  1. customThe mixture is evaporated

Sources & evidence

ORD record
ord-ada92a73568243c9addd637e5f2f42ff
Source dataset
uspto-grants-1977_09
Patent number
US04051173

Reaction notes

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