Methyl Isocyanate → HCID 21409338, compound

HRID 2072421Notes

Reaction equation

HRID 2072421 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:12][N:13]=[C:14]=[O:15]>O1CCCC1.C(N(CC)CC)C>[CH3:12][NH:13][C:14](=[O:15])[O:11][C:4]1[CH:5]=[CH:6][C:7]([N+:8]([O-:10])=[O:9])=[C:2]([CH3:1])[CH:3]=1

Participants

5

Reactant 2

HCID 12228Methyl IsocyanateHCID 174123-Methyl-4-nitrophenol

Product 1

HCID 21409338HCID 21409338, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8471TriethylamineSolvent

Procedure

3-Methyl-4-nitrophenol (46.0g., 0.30 mole) was dissolved in tetrahydrofuran (200 ml.) and triethylamine (2 ml.). To this solution was added dropwise methylisocyanate (18.8g., 0.33 mole, 25 ml.) which resulted in an exotherm to about 40° C. Refluxing for one hour, followed by quenching in excess water, yieldig a light tan precipitate. After filtration and drying the material (51g.) melted at .99°-101° C.

Workup

  1. customresulted in an exotherm to about 40° C
  2. temperatureRefluxing for one hour
  3. customby quenching in excess water
  4. filtrationAfter filtration
  5. dry with materialdrying the material (51g.) melted at .99°-101° C.

Sources & evidence

ORD record
ord-a92841fabf55417f9667d201ac6ee693
Source dataset
uspto-grants-1977_09
Patent number
US04051254

Reaction notes

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