Methylamine → HCID 59312251, compound

HRID 2077046Notes

Reaction equation

HRID 2077046 reaction equation
[F:1][C:2]1[CH:34]=[CH:33][C:5]([CH2:6][C:7]2[N:8]=[C:9](OS(C(F)(F)F)(=O)=O)[C:10]3[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12][C:11]=3[N:24]=2)=[CH:4][CH:3]=1.[CH3:35][NH2:36].C1COCC1>CC(N(C)C)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]2[N:8]=[C:9]([NH:36][CH3:35])[C:10]3[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12][C:11]=3[N:24]=2)=[CH:33][CH:34]=1

Participants

5

Reactant 3

HCID 6329MethylamineHCID 8028TetrahydrofuranHCID 59312317HCID 59312317, compound

Product 1

HCID 59312251HCID 59312251, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

To a solution of the triflate from Step C (90.0 mg, 0.18 mmol) in DMA (2 mL) was added methylamine solution in THF (0.45 mL, 2.0M, 0.89 mmol) and the reaction was stirred for 48 h. The reaction mixture was concentrated in vacuo and the material was used without further purification. A quantitative yield was assumed. LRMS ES+ and AP+ m/z 387 [MH]+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe material was used without further purification

Sources & evidence

ORD record
ord-349a2633ccb448e69ed0078fe5270624
Source dataset
uspto-grants-2011_04
Patent number
US07928099B2

Reaction notes

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