Isopropanol → HCID 22595773, compound

To a mixture of isopropanol (2 mL) and tetrahydrofuran (2 mL) was added sodium hydride (66%, 58 mg, 1.6 mmol) on an ice bath, then, the solution was stirred for 20 minutes at room temperature. To the reaction solution was added a solution of tributyl-iodomethyl-stannane (230 mg, 0.53 mmol), synthesized according to the document (Synthetic Communications, Vol. 24, No. 8, pp. 1117-1120), in tetrahydrofuran (1 mL) dropwise on an ice bath, then, N,N-dimethylformamide (0.5 mL) was added thereto, followed by stirring overnight at room temperature. The reaction solution was partitioned into water (20 mL) and diethyl ether (50 mL). The organic layer was separated, washed with brine, and then, evaporated in vacuo. The residue was purified by neutral silica gel column chromatography (heptane:ethyl acetate=30:1), and the title compound (63 mg, 0.17 mmol, 32%) was obtained as a colorless oil.

1. customsynthesized
2. stirringby stirring overnight at room temperature
3. customThe reaction solution was partitioned into water (20 mL) and diethyl ether (50 mL)
4. customThe organic layer was separated
5. washwashed with brine
6. customevaporated in vacuo
7. customThe residue was purified by neutral silica gel column chromatography (heptane:ethyl acetate=30:1)

ORD record

ord-0a64e9b5e7a04e7a8baaa927c2f6bd5f

Source dataset

uspto-grants-2011_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07932272B2