反应详情

The compound (520 mg) obtained in Example 23-4 was dissolved in anhydrous DMF (10 ml) and added with diisopropylethylamine (463 μl) and diethyl bromomalonate (340 μl) and the whole was stirred at room temperature for 2 hours. After completion of the reaction, a saturated aqueous sodium hydrogen carbonate solution was added thereto and the whole was stirred for a while. The solution was subjected to extraction with chloroform and washed with a saturated saline solution. The organic layer was dried with anhydrous sodium sulfate. The solvent was distilled off. The residue was purified through silica gel column chromatography (hexane/ethyl acetate), thereby obtaining the subject compound (421 mg) as a colorless oily substance.

1. customAfter completion of the reaction
2. stirringthe whole was stirred for a while
3. extractionThe solution was subjected to extraction with chloroform
4. washwashed with a saturated saline solution
5. dry with materialThe organic layer was dried with anhydrous sodium sulfate
6. distillationThe solvent was distilled off
7. customThe residue was purified through silica gel column chromatography (hexane/ethyl acetate)