Lithium Hydroxide → HCID 19799188, compound

HRID 2081175Notes

Reaction equation

HRID 2081175 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][O:7][CH2:8][CH2:9][NH:10][OH:11].[C:12](Cl)(=[O:14])[CH3:13].C(N(CC)CC)C.[Li+].[OH-]>CC(O)C>[OH:11][N:10]([CH2:9][CH2:8][O:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[C:12](=[O:14])[CH3:13]

Participants

6

Reactant 4

HCID 3939Lithium HydroxideHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 19799190HCID 19799190, compound

Product 1

HCID 19799188HCID 19799188, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The title compound is prepared from 2-(thien-2-ylmethoxy)ethyl hydroxylamine from Example 19 by first reaction with 3 equivalents of acetyl chloride and 3.3 equivalents of triethylamine followed by treatment with LiOH in 2-propanol.

Sources & evidence

ORD record
ord-4a5da4b074b7477ea3ca3896b1c2f032
Source dataset
uspto-grants-1993_02
Patent number
US05183818

Reaction notes

Loading…