Isopropyl iodide → HCID 10199064, compound

HRID 2084045Notes

Reaction equation

HRID 2084045 reaction equation
[CH2:1]([N:3]([CH2:15][CH3:16])[CH2:4][CH2:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1)[CH3:2].I[CH:18]([CH3:20])[CH3:19].[H-].[Na+].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C1(C)C=CC=CC=1>[CH2:15]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][N:12]2[CH:18]([CH3:20])[CH3:19])=[CH:8][CH:7]=1)[CH3:16]

Participants

7

Reactant 4

HCID 6362Isopropyl iodideHCID 11430Potassium CarbonateHCID 24758Sodium hydrideHCID 10036272HCID 10036272, compound

Product 1

HCID 10199064HCID 10199064, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6228DimethylformamideSolvent

Procedure

Prepared from 6-(2-(Diethylamino)ethyl)-indole (14 mg, 0.0647 mmol), 2-iodopropane (44 μl, 0.259 mmol), NaH (3.1 mg, 0.129 mmol), K2CO3 (35 mg, 0.259 mmol) in 0.1 ml of DMF and 0.5 ml of toluene, according to example. Yield 8.5 mg (51%).

Sources & evidence

ORD record
ord-8c8d706cecf44a9a80d94e2ad160031c
Source dataset
uspto-grants-2004_04
Patent number
US06716837B1

Reaction notes

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