Dimethylcarbamoyl Chloride → HCID 9903906, compound

HRID 2084055Notes

Reaction equation

HRID 2084055 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH:12]=[CH:13][NH:14]3)=[CH:10][CH:9]=2)=[CH:4][CH2:3]1.[CH3:17][N:18]([CH3:22])[C:19](Cl)=[O:20].C[Si]([N-][Si](C)(C)C)(C)C.[Na+]>C1COCC1>[CH3:17][N:18]([CH3:22])[C:19]([N:14]1[C:15]2[C:11](=[CH:10][CH:9]=[C:8]([C:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH:4]=3)[CH:16]=2)[CH:12]=[CH:13]1)=[O:20]

Participants

5

Reactant 3

HCID 6598Dimethylcarbamoyl ChlorideHCID 2724254Sodium bis(trimethylsilyl)amideHCID 101305596-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

Product 1

HCID 9903906HCID 9903906, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

From 6-(1-Methyl-1,2,5,6-tetrahydropyridin-4-yl)-indole (16.6 mg, 0.0735 mmol), dimethylcarbamyl chloride (15.8 mg. 0.147 mmol) and 1M NaN(TMS)2(0.147ml) in 0.5 ml of THF at 0° C. Yield 12.5 mg (60%), the reaction being carried out according to Example 6.

Workup

  1. customat 0° C

Sources & evidence

ORD record
ord-a802f2fc95d04ee796d6ed0c52d798c1
Source dataset
uspto-grants-2004_04
Patent number
US06716837B1

Reaction notes

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