反应详情

温度

0 °C

A solution of 2,2-dimethoxyethylamine (3 g) and triethylamine (4.318 g) in tetrahydrofuran (120 ml) was treated portionwise at 0° C. with 6-chloronaphthalene-2-sulfonyl chloride (7.45 g) and stirred at 0° C. for 30 minutes. The reaction mixture was combined with water and ethyl acetate to separate the organic phase, which was washed with an aqueous solution of citric acid and brine, dried and concentrated to obtain N-(2,2-dimethoxyethyl)-6-chloro-2-naphthalenesulfonamide as a colorless oil.

1. customto separate the organic phase, which
2. washwas washed with an aqueous solution of citric acid and brine
3. customdried
4. concentrationconcentrated