反应详情

484 mg of potassium carbonate and 456 mg of methyl iodide were added to an N,N-dimethylformamide (5 mL) solution of 1.00 g of 7-chloro-3-(2,6-dichlorophenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one obtained in Production Example 1, and stirred at room temperature for 1 hour. The reaction solution was added to ethyl acetate and aqueous 0.5 N hydrochloric acid solution with stirring, and the organic layer was separated. This was washed with saturated saline water, dried with anhydrous sodium sulfate, and the solvent was evaporated away. The crude product was solidified from chloroform/methanol/hexane to obtain 700 mg of the entitled compound as a yellow solid.

1. customobtained in Production Example 1
2. stirringwith stirring
3. customthe organic layer was separated
4. washThis was washed with saturated saline water
5. dry with materialdried with anhydrous sodium sulfate
6. customthe solvent was evaporated away