反应详情

To a mixture of cyclohexyl(3-methylthieno[3,2-b]pyridin-2-yl)methanone (1.38 g) synthesized above, methyl 4-aminobenzoate (884 mg), triethylamine (5.94 mL) and methylene chloride (30 mL) was added titanium (IV) chloride (700 μL) at 0° C., and the mixture was stirred at room temperature for 3.5 days under argon atmosphere. Saturated aqueous sodium hydrogen carbonate solution was added to quench the reaction, and the reaction mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give a dark brown oil. To a solution (30 mL) of the obtained oil in tetrahydrofuran were added acetic acid (607 μL) and sodium cyanoborohydride (666 mg), and the mixture was stirred at room temperature for 1 hr. Saturated aqueous sodium hydrogen carbonate solution was added to quench the reaction, and the reaction mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (10-50% ethyl acetate/hexane) to give the title object compound (1.31 g, 62%) as a brown solid.

1. customto quench
2. customthe reaction
3. extractionthe reaction mixture was extracted with ethyl acetate
4. washThe extract was washed with saturated brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. customto give a dark brown oil
8. stirringthe mixture was stirred at room temperature for 1 hr
9. customto quench
10. customthe reaction
11. extractionthe reaction mixture was extracted with ethyl acetate
12. washThe extract was washed with saturated brine
13. dry with materialdried over magnesium sulfate
14. concentrationconcentrated under reduced pressure
15. customThe residue was purified by silica gel column chromatography (10-50% ethyl acetate/hexane)