Sodium Iodide → HCID 68908797, compound

HRID 2102641Notes

Reaction equation

[CH2:1]([CH:6]1[CH2:12][CH:11]2[NH:13][CH:8]([CH2:9][CH2:10]2)[CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].[Na+].[I-].C([O-])([O-])=O.[K+].[K+].[CH3:22][N:23]([CH:25]=[O:26])[CH3:24]>>[CH3:8][C@H:9]([CH2:10][N:13]1[CH:11]2[CH2:10][CH2:9][C@H:8]1[CH2:7][CH:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH2:12]2)[CH2:22][N:23]1[C:24]2[C:3](=[CH:2][CH:1]=[CH:6][CH:7]=2)[CH2:4][CH2:5][C:25]1=[O:26]

Participants

Reactant 4

HCID 5238Sodium Iodide

HCID 6228Dimethylformamide

HCID 11430Potassium Carbonate

HCID 219898523-Pentyl-8-azabicyclo[3.2.1]octane

Product 1

HCID 68908797HCID 68908797, compound

Procedure

Crude (R,S)-1-(3-chloro-2-methylpropyl)-3,4-dihydro-1H-quinolin-2-one (107LH63) (0.094 g), 3-pentyl-8-azabicyclo[3.2.1]octane (0.027 g, 0.15 mmol), NaI (0.100 g, 0.67 mmol), and K2CO3 (0.075 g, 0.54 mmol) in DMF (1 mL) were reacted and purified according to GP20 to give the title compound (107LH74-c5) (0.023 g). HPLC-MS (ammonium acetate) [M+H]+=383.34.

Workup

custompurified

Sources & evidence

ORD record: ord-844924033ac642fc8bff035a60fd1791
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07576078B2

Reaction notes

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