1,2-Dichloroethane → HCID 11784862, compound

HRID 2106463Notes

Reaction equation

HRID 2106463 reaction equation
[CH3:1][C:2]([CH3:33])([CH3:32])[C:3](=[O:31])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:17]2[CH:18]=[CH:19][C:20]3[O:24][C:23]([C:25](O)=[O:26])=[C:22]([CH3:28])[C:21]=3[CH:29]=2)([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:8][C:7]=1[CH3:30].C(Cl)CCl.Cl.[CH3:39][NH:40][CH3:41]>CN(C1C=CN=CC=1)C>[CH3:39][N:40]([CH3:41])[C:25]([C:23]1[O:24][C:20]2[CH:19]=[CH:18][C:17]([C:12]([C:9]3[CH:10]=[CH:11][C:6]([O:5][CH2:4][C:3](=[O:31])[C:2]([CH3:33])([CH3:32])[CH3:1])=[C:7]([CH3:30])[CH:8]=3)([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:29][C:21]=2[C:22]=1[CH3:28])=[O:26]

Participants

5

Reactant 3

HCID 111,2-DichloroethaneHCID 10473Dimethylamine, hydrochlorideHCID 11328417HCID 11328417, compound

Product 1

HCID 11784862HCID 11784862, compoundYield 37.2%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

5-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-3-methyl-benzofuran-2-carboxylic acid (520 mg, 1.154 mmol), DMAP (422 mg, 3.46 mmol), EDC (332 mg, 1.73 mmol), and dimethyl amine hydrochloride (141 mg, 1.73 mmol) are reacted analogous to Example 1, step I to give the title product (205 mg, 37%).

Sources & evidence

ORD record
ord-fc0dc5ae65ca491aa04a8edcc5a7bd6b
Source dataset
uspto-grants-2009_08
Patent number
US07579488B2

Reaction notes

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