Diethylamine → Ethyl 2-(diethylamino)-1,3-thiazole-4-carboxylate

HRID 2107255Notes

Reaction equation

HRID 2107255 reaction equation
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].Cl[C:7]1[S:8][CH:9]=[C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:11]=1.C(N(CC)CC)C>CN(C)C=O>[CH2:1]([N:3]([CH2:4][CH3:5])[C:7]1[S:8][CH:9]=[C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:11]=1)[CH3:2]

Participants

5

Reactant 3

HCID 8021DiethylamineHCID 8471TriethylamineHCID 13106141Ethyl 2-chlorothiazole-4-carboxylate

Product 1

HCID 12966399Ethyl 2-(diethylamino)-1,3-thiazole-4-carboxylate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The reaction described in Preparation 26 was repeated, but using 2.3 g of diethylamine, 4 g of ethyl 2-chlorothiazole-4-carboxylate, 4.2 g of triethylamine, and 15 ml of dimethylformamide, giving ethyl 2-diethylaminothiazole-4-carboxylate as a pale yellow oil.

Workup

  1. customThe reaction described in Preparation 26

Sources & evidence

ORD record
ord-b3702451474c4f5f89fa7fae49e286ae
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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