反应详情

To a solution of tert-butyl 1-formylcyclopentylcarbamate (1.87 g, 8.78 mmol) in anhydrous THF (9 mL) was added 2,4-dimethoxylbenzylamine (1.98 mL, 13.17 mmol). The reaction was stirred for 10 min, treated with sodium triacetoxyborohydride (2.98 g, 14.04 mmol), and stirred for an additional 2 h at room temperature under an atmosphere of nitrogen. Saturated aqueous NaHCO3 solution was added and the mixture stirred until gas evolution ceased. The mixture was diluted with EtOAc, and the separated aqueous layer was saturated with NaCl and extracted into EtOAc once more. The combined organics were dried over Na2SO4, filtered, and concentrated in vacuo to afford the product.

1. stirringstirred for an additional 2 h at room temperature under an atmosphere of nitrogen
2. stirringthe mixture stirred until gas evolution
3. extractionextracted into EtOAc once more
4. dry with materialThe combined organics were dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customto afford the product