4-Methylmorpholine → HCID 60668515, compound

HRID 2117794Notes

Reaction equation

HRID 2117794 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[C:11]([OH:13])=O)[CH:4]=[CH:3][CH:2]=1.Cl.[NH2:15][CH2:16][C:17]([NH2:19])=[O:18].CN1CCOCC1.C1C=NC2N(O)N=NC=2C=1.Cl.CN(C)CCCN=C=NCC>CN(C=O)C>[C:17]([CH2:16][NH:15][C:11]([C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[N:1]=[CH:2][CH:3]=[CH:4]2)=[O:13])(=[O:18])[NH2:19]

Participants

7

Reactant 5

HCID 79724-MethylmorpholineHCID 665828-Quinolinecarboxylic acidHCID 181649HOAtHCID 2723639Glycinamide hydrochlorideHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Product 1

HCID 60668515HCID 60668515, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a mixture of quinoline-8-carboxylic acid (3.45 mmol), glycinamide hydrochloride (3.45 mmol), NMM (41.43 mmol) and HOAt (4.14 mmol) in DMF (17 mL) at room temperature was added 1-[3-(dimethylamino)propyl]-3-ethylcarbodimide hydrochloride (4.14 mmol). After stirring at room temperature overnight, the reaction mixture was purified by HPLC to afford the title compound as a white solid. MH+230.

Workup

  1. customthe reaction mixture was purified by HPLC

Sources & evidence

ORD record
ord-fd4d76e6084e421ab4baa4280d3632fc
Source dataset
uspto-grants-2008_10
Patent number
US07442793B2

Reaction notes

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