Methyl iodide → 4-Cyclohexylidene butanoic acid, methyl ester

Temperature

60 °C

A twice hexane washed suspension of 15.0 g (312 mmol) sodium hydride (50% in mineral oil) in 600 ml of dry dimethyl sulfoxide was heated under nitrogen at 60° C. for 1.5 hour, cooled to 15° C., and treated portionwise over 15 min with 60 g (140 mmol) of 3-carboxypropyl triphenylphosphonium bromide. The bright red solution was stirred at room temperature for 1 hour, then treated with 9.6 ml (93 mmol) of cyclohexanone in 100 ml of dry tetrahydrofuran, stirred 1 hour at room temperature, 2 hours at 40°-45° C., cooled to 0° C., quenched with 10 ml of water, diluted with 600 ml of ice water containing 50 ml of concentrated sulfuric acid and 250 ml of brine, and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The resulting yellow oil was dissolved in 500 ml of acetonitrile, degassed, treated with 25 ml (143 mmol) of diisopropylethylamine and 50 ml (792 mmol) of methyliodide, stirred for 18 hours under nitrogen at room temperature, diluted with 250 ml of ethyl acetate, washed with 5% sodium sulfate and with saturated aqueous sodium bicarbonate. The organic layers were washed with brine, dried over anhydrous sodium sulfate, filtered, concentrated in vacuo, and chromatographed on Silica Gel eluting with ethyl acetate in hexane to give 11.43 g (68%) of the title compound as a pale yellow oil.

1. washA twice hexane washed
2. temperaturecooled to 15° C.
3. stirringstirred 1 hour at room temperature, 2 hours at 40°-45° C.
4. temperaturecooled to 0° C.
5. customquenched with 10 ml of water
6. additiondiluted with 600 ml of ice water containing 50 ml of concentrated sulfuric acid and 250 ml of brine
7. extractionextracted with ethyl acetate
8. washThe combined organic layers were washed with brine
9. dry with materialdried over anhydrous sodium sulfate
10. filtrationfiltered
11. concentrationconcentrated in vacuo
12. dissolutionThe resulting yellow oil was dissolved in 500 ml of acetonitrile
13. customdegassed
14. stirringstirred for 18 hours under nitrogen at room temperature
15. washwashed with 5% sodium sulfate and with saturated aqueous sodium bicarbonate
16. washThe organic layers were washed with brine
17. dry with materialdried over anhydrous sodium sulfate
18. filtrationfiltered
19. concentrationconcentrated in vacuo
20. customchromatographed on Silica Gel eluting with ethyl acetate in hexane

ORD record

ord-39a4b3653cc74489ac57ca47786dd4ba

Source dataset

uspto-grants-1987_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04683330