反应详情

Demethylation of dimethyl 1-eicosanyloxycarbonylphosphonate with NaI was carried out as described in Example 8 above except for the solvent, which was a mixture of DMF (3 mL), THF (8 mL), and acetone (2 mL); yield 0.86 g (84%); mp 95-96° C.; IR (KBr): υ 2960, 2930, 2860, 1735, 1470, 1235, 1220 cm−1; 1H NMR (CDCl3+CD2OD) δ0.8-1.8 (m, 39H, CH3(CH2)18), 3.8 (d, 3H, P(ONa)(OCH3)), 4.2 (t, 2H, CH2O). Anal. Calcd. for C22H44O5NaP: C, 59.69; H, 10.04; N, 5.19; P, 7.00. Found: C, 59.94; H, 10.00; Na, 5.19; P, 7.06.