1,2-Dichloroethane → HCID 22034100, compound

HRID 2121615Notes

Reaction equation

HRID 2121615 reaction equation
[CH3:1][C:2]1[C:3]([O:14][C:15]2[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=2[CH3:23])=[N:4][C:5]([CH3:13])=[CH:6][C:7]=1[NH:8][CH2:9][CH2:10][NH:11]C.[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH2:34][C:35]([OH:37])=O)[CH:29]=[CH:30][C:31]=1[O:32][CH3:33].C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C.CCOC(C)=O>[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH2:34][C:35]([NH:11][CH2:10][CH2:9][NH:8][C:7]2[CH:6]=[C:5]([CH3:13])[N:4]=[C:3]([O:14][C:15]3[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=3[CH3:23])[C:2]=2[CH3:1])=[O:37])[CH:29]=[CH:30][C:31]=1[O:32][CH3:33]

Participants

7

Reactant 4

HCID 111,2-DichloroethaneHCID 7139(3,4-Dimethoxyphenyl)acetic acidHCID 757711-HydroxybenzotriazoleHCID 22034134HCID 22034134, compound

Product 1

HCID 22034100HCID 22034100, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

Stir a solution of [3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-4-pyridyl][2-(methylamino)ethyl]amine (68 mg, 0.23 mmol), 3,4-dimethoxyphenylacetic acid (59 mg, 0.3 mmol), EDC (59 mg, 0.3 mmol) and HOBT (41 mg, 0.3 mmol) in DMF (1.0 mL) for 12 h. Dilute the reaction mixture with EtOAc (10 mL) and wash with saturated aq NaHCO3 (2×10 mL) and saturated aq brine (2×10 mL), dry and concentrate in vacuo to obtain the title compound as an oily residue. M+1: 478.

Workup

  1. washwash with saturated aq NaHCO3 (2×10 mL) and saturated aq brine (2×10 mL)
  2. customdry
  3. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-7194da04bf324329a21b09d07a2b725a
Source dataset
uspto-grants-2004_02
Patent number
US06696445B2

Reaction notes

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