1,2-Dichloroethane → (R/S)-3-(2-Furylmethyl)amino 1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

HRID 2124532Notes

Reaction equation

HRID 2124532 reaction equation
[C:29]([O:30][BH-:31]([O:32][C:33](=[O:34])[CH3:35])[O:36][C:37](=[O:38])[CH3:39])(=[O:40])[CH3:41].[CH3:52][CH2:53][N:54]([CH2:55][CH3:56])[CH2:57][CH3:58].[CH:22]([c:23]1[cH:24][cH:25][cH:26][o:27]1)=[O:28].[Cl:48][CH2:49][CH2:50][Cl:51].[ClH:1].[NH2:2][CH:3]1[CH2:4][N:5]([S:8](=[O:9])(=[O:10])[c:11]2[c:12]3[c:13]([Br:21])[cH:14][n:15][cH:16][c:17]3[cH:18][cH:19][cH:20]2)[CH2:6][CH2:7]1.[Na+:42].[Na+:43].[OH:44][C:45](=[O:46])[O-:47]>>[NH:2]([CH:3]1[CH2:4][N:5]([S:8](=[O:9])(=[O:10])[c:11]2[c:12]3[c:13]([Br:21])[cH:14][n:15][cH:16][c:17]3[cH:18][cH:19][cH:20]2)[CH2:6][CH2:7]1)[CH2:22][c:23]1[cH:24][cH:25][cH:26][o:27]1

Participants

9

Reactant 8

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 7362FurfuralHCID 8471TriethylamineHCID 2724942TriacetoxyborohydrideHCID 672429043-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Product 1

HCID 67244220(R/S)-3-(2-Furylmethyl)amino 1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Sources & evidence

ORD record
ord-2ef1f01a24ba448097b8a3118224e80f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…