Chlorotrimethylsilane → tert-Butyl 3-(pyrimidin-2-ylmethyl)piperidine-1-carboxylate
Reaction equation
[Br:1][CH2:2][CH2:3][Br:4].[CH2:54]1[O:55][CH2:56][CH2:57][CH2:58]1.[CH3:59][CH2:60][O:61][C:62](=[O:63])[CH3:64].[CH:66](=[CH:67][C:68]([CH:69]=[CH:70][c:71]1[cH:72][cH:73][cH:74][cH:75][cH:76]1)=[O:77])[c:78]1[cH:79][cH:80][cH:81][cH:82][cH:83]1.[CH:84](=[CH:85][C:86]([CH:87]=[CH:88][c:89]1[cH:90][cH:91][cH:92][cH:93][cH:94]1)=[O:95])[c:96]1[cH:97][cH:98][cH:99][cH:100][cH:101]1.[Cl:25][c:26]1[n:27][cH:28][cH:29][cH:30][n:31]1.[Cl:5][Si:6]([CH3:7])([CH3:8])[CH3:9].[I:10][CH2:11][CH:12]1[CH2:13][N:14]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:15][CH2:16][CH2:17]1.[Pd:65].[c:32]1([CH3:33])[cH:34][cH:35][cH:36][cH:37][c:38]1[P:39]([c:40]1[cH:41][cH:42][cH:43][cH:44][c:45]1[CH3:46])[c:47]1[cH:48][cH:49][cH:50][cH:51][c:52]1[CH3:53]>>[CH2:11]([CH:12]1[CH2:13][N:14]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:15][CH2:16][CH2:17]1)[c:26]1[n:27][cH:28][cH:29][cH:30][n:31]1Participants
10
Reactant 9
Product 1
Sources & evidence
- ORD record
- ord-90c4e52443104cb68ffe506edfd4e34b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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