1,2-Dichloroethane → (5-{5-[(5-Bromo-pyridine-2-carbonyl)amino]-2-fluoro-phenyl}-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester
Reaction equation
[Br:26][c:27]1[cH:28][cH:29][c:30]([C:33](=[O:34])[OH:35])[n:31][cH:32]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([CH:14]([F:15])[F:16])([c:17]2[c:18]([F:24])[cH:19][cH:20][c:21]([NH2:23])[cH:22]2)[CH2:11][O:10][CH2:9]1)=[O:25].[CH2:43]([Cl:44])[CH2:45][Cl:46].[CH3:36][CH2:37][N:38]([CH2:39][CH3:40])[CH2:41][CH3:42].[CH3:51][CH2:52][O:53][C:54]([CH3:55])=[O:56].[Cl:48][CH2:49][Cl:50].[ClH:47]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([CH:14]([F:15])[F:16])([c:17]2[c:18]([F:24])[cH:19][cH:20][c:21]([NH:23][C:33]([c:30]3[cH:29][cH:28][c:27]([Br:26])[cH:32][n:31]3)=[O:34])[cH:22]2)[CH2:11][O:10][CH2:9]1)=[O:25]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-acc9562454ef446ab9c0be37a3e54107
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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