Hydrochloric Acid → 2-(5-methoxy-2-pyridinyl)-1-[2-[5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone

HRID 2135723Notes

Reaction equation

HRID 2135723 reaction equation
[C:13]([n:14]1[cH:15][cH:16][n:17][cH:18]1)([n:19]1[cH:20][cH:21][n:22][cH:23]1)=[O:24].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:9][C:10](=[O:11])[OH:12])[n:7][cH:8]1.[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[CH3:34][c:35]1[cH:36][c:37](-[c:41]2[cH:42][c:43]3[c:47]([cH:48][cH:49]2)[CH:46]([N:50]2[CH2:51][C:52]4([CH2:53]2)[CH2:54][CH2:55][NH:56][CH2:57][CH2:58]4)[CH2:45][CH2:44]3)[n:38][cH:39][n:40]1.[CH3:64][CH2:65][O:66][C:67]([CH3:68])=[O:69].[Cl:61][CH2:62][Cl:63].[ClH:32].[ClH:33].[Na+:60].[OH-:59].[OH2:70]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:9][C:10](=[O:12])[N:56]2[CH2:55][CH2:54][C:52]3([CH2:51][N:50]([CH:46]4[CH2:45][CH2:44][c:43]5[cH:42][c:41](-[c:37]6[cH:36][c:35]([CH3:34])[n:40][cH:39][n:38]6)[cH:49][cH:48][c:47]54)[CH2:53]3)[CH2:58][CH2:57]2)[n:7][cH:8]1

Participants

11

Reactant 10

HCID 313Hydrochloric Acid2×HCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 6344DichloromethaneHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 682631,1'-CarbonyldiimidazoleHCID 584384902-(5-Methoxypyridin-2-yl)acetic acidHCID 674060902-[5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonane

Product 1

HCID 533912162-(5-methoxy-2-pyridinyl)-1-[2-[5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]nonan-7-yl]ethanone

Sources & evidence

ORD record
ord-80f560a418ba4d748d73370fbf6ad5ff
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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