Dimethylformamide → 4-(4-bromo-2-fluorophenylamino)-N-(cyclopropylmethoxy)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide

HRID 2138400Notes

Reaction equation

HRID 2138400 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:20])[c:5]([NH:8][c:9]2[c:10]([C:17](=[O:18])[OH:19])[cH:11][n:12]([CH3:16])[c:13](=[O:15])[cH:14]2)[cH:6][cH:7]1.[CH3:21][CH2:22][N:23]=[C:24]=[N:25][CH2:26][CH2:27][CH2:28][N:29]([CH3:30])[CH3:31].[CH3:48][CH2:49][N:50]([CH2:51][CH3:52])[CH2:53][CH3:54].[CH3:60][CH2:61][O:62][C:63]([CH3:64])=[O:65].[CH:42]1([CH2:45][O:46][NH2:47])[CH2:43][CH2:44]1.[O:55]=[CH:56][N:57]([CH3:58])[CH3:59].[OH:32][n:33]1[c:34]2[c:35]([cH:36][cH:37][cH:38][cH:39]2)[n:40][n:41]1>>[Br:1][c:2]1[cH:3][c:4]([F:20])[c:5]([NH:8][c:9]2[c:10]([C:17](=[O:19])[NH:47][O:46][CH2:45][CH:42]3[CH2:43][CH2:44]3)[cH:11][n:12]([CH3:16])[c:13](=[O:15])[cH:14]2)[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 11182605O-(cyclopropylmethyl)hydroxylamineHCID 115809254-(4-Bromo-2-fluorophenylamino)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Product 1

HCID 116112414-(4-bromo-2-fluorophenylamino)-N-(cyclopropylmethoxy)-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide

Sources & evidence

ORD record
ord-aaeafb91bbbd4a53a87309b7ca022462
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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