Pyridine → Tert-butyl 1-(carbonochloridoyl)pyrrolidine-2-carboxylate

HRID 2140726Notes

Reaction equation

HRID 2140726 reaction equation
[CH3:64][N:65]([CH3:66])[c:67]1[cH:68][cH:69][n:70][cH:71][cH:72]1.[CH3:73][CH2:74][O:75][C:76](=[O:77])[CH3:78].[CH:13]([N:14]([CH:15]([CH3:16])[CH3:17])[CH2:18][CH3:19])([CH3:20])[CH3:21].[Cl:22][C:23]([O:26][C:24](=[O:25])[O:27][C:28]([Cl:29])([Cl:30])[Cl:31])([Cl:32])[Cl:33].[Cl:34][c:35]1[cH:36][cH:37][c:38]([OH:39])[c:40]([C:42]([NH:43][c:44]2[cH:45][cH:46][c:47]([N+:48]([O-:49])=[O:50])[cH:51][c:52]2[Cl:53])=[O:54])[cH:41]1.[Cl:55][CH2:56][Cl:57].[NH:1]1[CH:2]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[CH2:3][CH2:4][CH2:5]1.[cH:58]1[cH:59][cH:60][n:61][cH:62][cH:63]1>>[N:1]1([C:23]([Cl:22])=[O:26])[CH:2]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[CH2:3][CH2:4][CH2:5]1

Participants

9

Reactant 8

HCID 1049PyridineHCID 4477NiclosamideHCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 142844-(Dimethylamino)pyridineHCID 81531DiisopropylethylamineHCID 94429TriphosgeneHCID 102884tert-butyl L-prolinate

Product 1

HCID 14552296Tert-butyl 1-(carbonochloridoyl)pyrrolidine-2-carboxylate

Sources & evidence

ORD record
ord-138de76d2f7643f79a1a3768fcd3a3aa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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