Water → 6-(2,5-difluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]nicotinamide
Reaction equation
[CH3:30][CH2:31][N:32]=[C:33]=[N:34][CH2:35][CH2:36][CH2:37][N:38]([CH3:39])[CH3:40].[CH3:51][N:52]1[CH2:53][CH2:54][O:55][CH2:56][CH2:57]1.[CH3:58][CH2:59][O:60][C:61]([CH3:62])=[O:63].[CH3:65][N:66]([CH3:67])[C:68](=[O:69])[CH3:70].[F:18][C:19]([CH2:20][N:21]1[CH2:22][CH2:23][CH:24]([NH2:27])[CH2:25][CH2:26]1)([F:28])[F:29].[F:1][c:2]1[c:3](-[c:9]2[n:10][cH:11][c:12]([C:13](=[O:14])[OH:15])[cH:16][cH:17]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1.[OH2:64].[OH:41][n:42]1[c:43]2[c:44]([cH:45][cH:46][cH:47][cH:48]2)[n:49][n:50]1>>[F:1][c:2]1[c:3](-[c:9]2[n:10][cH:11][c:12]([C:13](=[O:15])[NH:27][CH:24]3[CH2:23][CH2:22][N:21]([CH2:20][C:19]([F:18])([F:28])[F:29])[CH2:26][CH2:25]3)[cH:16][cH:17]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-0b486e3e2d4a4108992ddd143f3784b7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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