Hydrochloric Acid → 2-(Azetidin-1-ylcarbonyl)-5-bromopyridine

HRID 214305Notes

Reaction equation

HRID 214305 reaction equation
[Br:7][c:8]1[cH:9][cH:10][c:11]([C:14](=[O:15])[OH:16])[n:12][cH:13]1.[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[Cl:1][C:2]([C:3]([Cl:4])=[O:5])=[O:6].[Cl:36][CH2:37][Cl:38].[ClH:23].[ClH:35].[NH:24]1[CH2:25][CH2:26][CH2:27]1.[O:17]1[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1.[O:39]=[CH:40][N:41]([CH3:42])[CH3:43]>>[Br:7][c:8]1[cH:9][cH:10][c:11]([C:14](=[O:16])[N:24]2[CH2:25][CH2:26][CH2:27]2)[n:12][cH:13]1

Participants

9

Reactant 8

HCID 313Hydrochloric Acid2×HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 10422AzetidineHCID 312751,4-DioxaneHCID 65578Oxalyl chlorideHCID 6085445-Bromopyridine-2-carboxylic acid

Product 1

HCID 536296172-(Azetidin-1-ylcarbonyl)-5-bromopyridine

Sources & evidence

ORD record
ord-59957663d6e148a3989115e615336f6a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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