Tetrahydrofuran → N-[5-(3-fluoro-phenylethynyl)-pyridin-2-yl]-2-methoxy-2-methyl-propionamide

HRID 2146460Notes

Reaction equation

HRID 2146460 reaction equation
[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:1][O:2][C:3]([C:4](=[O:5])[NH:6][c:7]1[n:8][cH:9][c:10]([C:13]#[C:14][Si:15]([CH3:16])([CH3:17])[CH3:18])[cH:11][cH:12]1)([CH3:19])[CH3:20].[CH3:29][CH2:30][N:31]([CH2:32][CH3:33])[CH2:34][CH3:35].[Cu:82][I:83].[F:21][c:22]1[cH:23][c:24]([I:28])[cH:25][cH:26][cH:27]1.[Pd:41]([Cl:42])[Cl:43].[c:44]1([P:45]([c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)[cH:58][cH:59][cH:60][cH:61][cH:62]1.[c:63]1([P:64]([c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)[cH:77][cH:78][cH:79][cH:80][cH:81]1>>[CH3:1][O:2][C:3]([C:4](=[O:5])[NH:6][c:7]1[n:8][cH:9][c:10]([C:13]#[C:14][c:24]2[cH:23][c:22]([F:21])[cH:27][cH:26][cH:25]2)[cH:11][cH:12]1)([CH3:19])[CH3:20]

Participants

8

Reactant 7

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 707251-Fluoro-3-iodobenzeneHCID 866808252-Methoxy-2-methyl-N-(5-trimethylsilanylethynyl-pyridin-2-yl)-propionamide

Product 1

HCID 71548343N-[5-(3-fluoro-phenylethynyl)-pyridin-2-yl]-2-methoxy-2-methyl-propionamide

Sources & evidence

ORD record
ord-6d74da7e07f74bb0bfa778fbb9eff25d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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