Diethyl Ether → 1-Methyl-4-(5-((trimethylsilyl)ethynyl)pyridin-2-yl)piperazine

HRID 2146972Notes

Reaction equation

[Br:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH2:13]2)[n:6][cH:7]1.[CH2:15]1[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1.[CH3:21][Si:22]([CH3:23])([CH3:24])[C:25]#[CH:26].[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[CH3:34][CH2:35][O:36][CH2:37][CH3:38].[Cu:39][I:40]>>[c:2]1([C:26]#[C:25][Si:22]([CH3:21])([CH3:23])[CH3:24])[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH2:13]2)[n:6][cH:7]1

Participants

Reactant 6

HCID 3283Diethyl Ether

HCID 8082Piperidine

HCID 8471Triethylamine

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 66111Trimethylsilylacetylene

HCID 164142065-Bromo-2-(4-methylpiperazin-1-yl)pyridine

Product 1

HCID 667304181-Methyl-4-(5-((trimethylsilyl)ethynyl)pyridin-2-yl)piperazine

Sources & evidence

ORD record: ord-d3a207b73bd24397aa9032c4148152fd
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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