Dimethylformamide → 7-(4-Bromo-2-chlorophenylamino)-8-fluoro-4-methylquinazoline-6-carboxylic acid (2-vinyloxy-ethoxy)-amide
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([Cl:24])[c:5]([NH:8][c:9]2[c:10]([C:21](=[O:22])[OH:23])[cH:11][c:12]3[c:13]([CH3:20])[n:14][cH:15][n:16][c:17]3[c:18]2[F:19])[cH:6][cH:7]1.[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH3:49][CH2:50][N:51]=[C:52]=[N:53][CH2:54][CH2:55][CH2:56][N:57]([CH3:58])[CH3:59].[CH3:65][CH2:66][O:67][C:68]([CH3:69])=[O:70].[CH:42](=[CH2:43])[O:44][CH2:45][CH2:46][O:47][NH2:48].[O:60]=[CH:61][N:62]([CH3:63])[CH3:64].[OH:25][n:26]1[c:27]2[c:28]([cH:29][cH:30][cH:31][cH:32]2)[n:33][n:34]1>>[Br:1][c:2]1[cH:3][c:4]([Cl:24])[c:5]([NH:8][c:9]2[c:10]([C:21](=[O:22])[NH:48][O:47][CH2:46][CH2:45][O:44][CH:42]=[CH2:43])[cH:11][c:12]3[c:13]([CH3:20])[n:14][cH:15][n:16][c:17]3[c:18]2[F:19])[cH:6][cH:7]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-42241d37fd2c4de28245abc9ba7115ef
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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