Tetrahydrofuran → Methyl 2-[2-methyl-4-[3-[4-(2-pyridin-2-ylethynyl)phenyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enoxy]phenoxy]acetate
Reaction equation
[C:35](#[CH:36])[c:37]1[n:38][cH:39][cH:40][cH:41][cH:42]1.[CH3:48][CH2:49][N:50]([CH2:51][CH3:52])[CH2:53][CH3:54].[Cu:132][I:133].[I:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[CH:9][CH2:10][O:11][c:12]2[cH:13][c:14]([CH3:24])[c:15]([O:16][CH2:17][C:18](=[O:19])[O:20][CH3:21])[cH:22][cH:23]2)[c:25]2[cH:26][cH:27][c:28]([C:31]([F:32])([F:33])[F:34])[cH:29][cH:30]2)[cH:6][cH:7]1.[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1.[cH:55]1[cH:56][cH:57][c:58]([P:59]([Pd:60]([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([P:80]([c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)([c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)[c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)[P:99]([c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)([c:106]2[cH:107][cH:108][cH:109][cH:110][cH:111]2)[c:112]2[cH:113][cH:114][cH:115][cH:116][cH:117]2)([c:118]2[cH:119][cH:120][cH:121][cH:122][cH:123]2)[c:124]2[cH:125][cH:126][cH:127][cH:128][cH:129]2)[cH:130][cH:131]1>>[c:2]1([C:36]#[C:35][c:37]2[n:38][cH:39][cH:40][cH:41][cH:42]2)[cH:3][cH:4][c:5]([C:8](=[CH:9][CH2:10][O:11][c:12]2[cH:13][c:14]([CH3:24])[c:15]([O:16][CH2:17][C:18](=[O:19])[O:20][CH3:21])[cH:22][cH:23]2)[c:25]2[cH:26][cH:27][c:28]([C:31]([F:32])([F:33])[F:34])[cH:29][cH:30]2)[cH:6][cH:7]1Participants
7
Reactant 6
HCID 8028Tetrahydrofuran
HCID 8471Triethylamine
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 137268Ethynylpyridine
HCID 91270331Methyl 2-[4-[3-(4-iodophenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-enoxy]-2-methylphenoxy]acetate
HCID 178420554HCID 178420554, compoundProduct 1
Sources & evidence
- ORD record
- ord-35c443e8c5474b44bc7f1cd63615d2a5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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