Triethylamine → Benzyl-[1-(4-trimethylsilanylethynyl-phenyl)cyclopropyl]-amine

HRID 2158845Notes

Reaction equation

HRID 2158845 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][C:9]1([c:12]2[cH:13][cH:14][c:15]([Br:18])[cH:16][cH:17]2)[CH2:10][CH2:11]1.[CH3:19][Si:20]([CH3:21])([CH3:22])[C:23]#[CH:24].[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[Cu:32][I:33].[Pd:34]([Cl:35])[Cl:36].[c:37]1([P:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[cH:51][cH:52][cH:53][cH:54][cH:55]1.[c:56]1([P:57]([c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)[c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[cH:70][cH:71][cH:72][cH:73][cH:74]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][C:9]1([c:12]2[cH:13][cH:14][c:15]([C:24]#[C:23][Si:20]([CH3:19])([CH3:21])[CH3:22])[cH:16][cH:17]2)[CH2:10][CH2:11]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 22568916HCID 22568916, compound

Product 1

HCID 22568959Benzyl-[1-(4-trimethylsilanylethynyl-phenyl)cyclopropyl]-amine

Sources & evidence

ORD record
ord-aa973cd44d6a4ac5b8679f06a7022e52
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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