Hydrochloric Acid → 5-Chloro-7-morpholinothiazolo[5,4-d]pyrimidine-2-carbaldehyde

HRID 2161191Notes

Reaction equation

HRID 2161191 reaction equation
[CH2:36]([c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[CH3:43].[CH2:56]([Cl:57])[Cl:58].[CH3:25][N:26]([CH:27]=[O:28])[CH3:29].[CH3:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH3:55].[CH:17]([N-:18][CH:19]([CH3:20])[CH3:21])([CH3:22])[CH3:23].[Cl:1][c:2]1[n:3][c:4]([N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[c:5]2[c:6]([n:7]1)[s:8][cH:9][n:10]2.[ClH:30].[Li+:24].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1.[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1>>[Cl:1][c:2]1[n:3][c:4]([N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([CH:27]=[O:28])[n:10]2

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 7500EthylbenzeneHCID 8028Tetrahydrofuran2×HCID 8900HeptaneHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 576853854-(5-Chlorothiazolo[5,4-d]pyrimidin-7-yl)morpholine

Product 1

HCID 576854055-Chloro-7-morpholinothiazolo[5,4-d]pyrimidine-2-carbaldehyde

Sources & evidence

ORD record
ord-20d50747f94b4a7e955632e41d070f9d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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