Water → 2-Fluoro-6-(methylamino)benzonitrile

HRID 2164446Notes

Reaction equation

HRID 2164446 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6](F)[C:3]=1[C:4]#[N:5].[CH3:11][NH2:12].O>CN(C=O)C>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([NH:12][CH3:11])[C:3]=1[C:4]#[N:5]

Participants

5

Reactant 3

HCID 962WaterHCID 6329MethylamineHCID 746952,6-Difluorobenzonitrile

Product 1

HCID 134697972-Fluoro-6-(methylamino)benzonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2,6-Difluorobenzonitrile, 2.78 g (20 mmol) and 5 ml (60 mmol) of 40% aqueous methylamine in 50 ml DMF is stirred at room temperature for 1 hr., poured into water and the product is collected, 2.4 g m.p. 130°-132° C.

Workup

  1. customthe product is collected

Sources & evidence

ORD record
ord-d54ade8330034c1ab3d36e8d8ce7f104
Source dataset
uspto-grants-1985_03
Patent number
US04504660

Reaction notes

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