Hydrochloric Acid → HCID 70873584, compound

HRID 2172208Notes

Reaction equation

HRID 2172208 reaction equation
[CH3:1][O:2][C:3](=[O:6])[CH2:4]Br.[F:7][C:8]([F:18])([F:17])[O:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+].Cl>CN(C)C=O.O>[CH3:1][O:2][C:3](=[O:6])[CH2:4][O:16][C:13]1[CH:14]=[CH:15][C:10]([O:9][C:8]([F:7])([F:17])[F:18])=[CH:11][CH:12]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 70015p-(Trifluoromethoxy)phenol

Product 1

HCID 70873584HCID 70873584, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

Bromoacetic acid methyl ester (8 ml, 84.2 mmol) was added to a mixture of 4-(trifluoromethoxy)phenol (10 g, 56.1 mmol) and potassium carbonate (11.6 g, 84.2 mmol) in N,N-Dimethylformamide (50 ml) and stirred at room temperature overnight. The reaction mixture was poured into water and neutralized with a 1 N hydrochloric acid aqueous solution, followed by extraction with diethylether. The result was concentrated and used for the subsequent reaction.

Workup

  1. extractionfollowed by extraction with diethylether
  2. concentrationThe result was concentrated
  3. customused for the subsequent reaction

Sources & evidence

ORD record
ord-f509cf6d25384e008fefe26745464569
Source dataset
uspto-grants-2015_06
Patent number
US09051333B2

Reaction notes

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