反应详情

NaOH (0.1 g, 2.4 mmol) was added to 2 ml of degassed dimethylformamide and 4-bromobenzylalcohol (0.3 g, 1.6 mmol) was further added slowly. Iodoethane (0.14 ml, 1.76 mmol) was added at room temperature followed by stirring for 2 hours. The mixture was added with 50 ml of 2N c HCl and extracted with 50 ml of ethylacetate. The organic layer was washed twice with 50 ml of H2O. After concentration under vacuum and column chromatography (ethylacetate/n-hexane, 1/10), the title compound (0.17 g, 48%) was obtained as yellowish oil.

1. additionwas further added slowly
2. extractionextracted with 50 ml of ethylacetate
3. washThe organic layer was washed twice with 50 ml of H2O
4. concentrationAfter concentration under vacuum and column chromatography (ethylacetate/n-hexane, 1/10)