Hydrogen Bromide → HCID 22491597, compound

HRID 2180210Notes

Reaction equation

HRID 2180210 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([P:9](=[O:22])([C:14]2[CH:19]=[CH:18][C:17]([O:20]C)=[CH:16][CH:15]=2)[C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:5][CH:4]=1.Br.[Br-].[K+].S([O-])([O-])=O.[Na+].[Na+].CBr>>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([P:9](=[O:22])([C:14]2[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=2)[C:10]([CH3:13])([CH3:11])[CH3:12])=[CH:5][CH:4]=1

Participants

6

Reactant 5

HCID 260Hydrogen BromideHCID 6323Methyl BromideHCID 24437Sodium SulfiteHCID 253877Potassium BromideHCID 69507613HCID 69507613, compound

Product 1

HCID 22491597HCID 22491597, compoundYield 42.1%

Procedure

Bis(4-methoxyphenyl)-tert-butylphosphine oxide mixture (25.0 g), hydrobromic acid (770 g, 48%), and potassium bromide (30.0 g) were stirred for 25 h at 120° C. The flask was fitted with a sodium sulfite scrubber for containment of methyl bromide. The reaction mixture was worked up to give a tan solid (9.6 g, 40%). 31P NMR (d6-DMSO): δ 46.3 (s, 31.8%), 39.6 (s, 31.7%), 28.7 (s, 20.4%), −8.2 (s, 16.1%).

Sources & evidence

ORD record
ord-024d58429446467db74f00130e656e91
Source dataset
uspto-grants-2005_05
Patent number
US06887950B2

Reaction notes

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