反应详情

温度

115 °C

A mixture of (S)-[1-(3-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (1 g, 4.2 mmol), 5-bromo-pyrimidine (0.8 g, 5.1 mmol), potassium carbonate (powder, 1.4 g, 10.1 mmol), copper iodide (325 mesh powder, 0.6 g, 3.2 mmol) and pyridine (5 mL) was heated at 115° C. for 24 h. CH2Cl2 (100 mL) was added, the reaction mixture was filtered through celite, rinsed with CH2Cl2 (2×50 mL), and the filtrate was concentrated in vacuo. The residue was purified by flash column chromatography on silica gel eluting with 1:1/Hexane:EtOAc to give the title product (0.81 g, 61% yield).

1. filtrationthe reaction mixture was filtered through celite
2. washrinsed with CH2Cl2 (2×50 mL)
3. concentrationthe filtrate was concentrated in vacuo
4. customThe residue was purified by flash column chromatography on silica gel eluting with 1:1/Hexane