Hydrochloric Acid → HCID 59741013, compound

HRID 2192152Notes

Reaction equation

HRID 2192152 reaction equation
[Cl:1]N1C(=O)CCC1=O.Cl.[F:10][C:11]([F:34])([F:33])[C:12]([NH:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([O:22][C:23]2[CH:28]=[CH:27][N:26]=[C:25]3[NH:29][CH:30]=[CH:31][C:24]=23)=[C:17]([F:32])[CH:16]=1)=[O:13]>O1CCCC1>[Cl:1][C:31]1[C:24]2[C:25](=[N:26][CH:27]=[CH:28][C:23]=2[O:22][C:18]2[C:19]([F:21])=[CH:20][C:15]([NH:14][C:12](=[O:13])[C:11]([F:10])([F:33])[F:34])=[CH:16][C:17]=2[F:32])[NH:29][CH:30]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 31398ChlorosuccinimideHCID 59740996HCID 59740996, compound

Product 1

HCID 59741013HCID 59741013, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

204 mg (1.54 mmol) of N-chlorosuccinimide and 50 μl of 1M aqueous hydrochloric acid are added to a solution of 250 mg (0.70 mmol) of 2,2,2-trifluoro-N-[3,5-difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]acetamide in anhydrous tetrahydrofuran (5 ml). The solution is stirred at RT overnight. The title compound precipitates from the reaction mixture. A solid is obtained by filtration with suction and drying.

Workup

  1. customThe title compound precipitates from the reaction mixture
  2. customA solid is obtained by filtration with suction
  3. customdrying

Sources & evidence

ORD record
ord-fd9316e724964eb88d7b5037b316d1cf
Source dataset
uspto-grants-2012_12
Patent number
US08329716B2

Reaction notes

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