Methylamine → HCID 20517518, compound

HRID 2198894Notes

Reaction equation

[I-].[CH3:2][S+](C)(C)=O.CO[CH:9]([CH3:19])[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12].[H-].[Na+].[O:22]1C[CH2:23]1.[CH3:25][NH2:26]>>[CH3:23][O:22][C:17]1[CH:18]=[C:13]([C:11]([CH2:25][NH:26][CH3:2])([CH2:10][CH2:9][CH3:19])[OH:12])[CH:14]=[CH:15][CH:16]=1

Participants

Reactant 5

HCID 6329Methylamine

HCID 6354Ethylene Oxide

HCID 24758Sodium hydride

HCID 74498Sulfoxonium, trimethyl-, iodide (1:1)

HCID 130659403-Methoxy-1-phenylbutan-1-one

Product 1

HCID 20517518HCID 20517518, compound

Procedure

Following the method of Example 1,2-(3-methoxyphenyl)-2-propyloxiran was prepared from trimethylsulphoxonium iodide, 3-methoxybutyrophenone and sodium hydride. The oxiran was treated with 33% ethanolic methylamine affording 3-methoxy-α-[(methylamino)methyl]-α-propylbenzenemethanol isolated as the hydrochloride salt m.p. 168°-70° C.

Sources & evidence

ORD record: ord-2bf52759f51a40aa8637394bfe7fb81c
Source dataset: uspto-grants-1982_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04360519

Reaction notes

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