反应详情

To a solution of 4-bromo-2-hydroxy-5-(4-morpholinylmethyl)benzoic acid (may be prepared as described in Description 33; 302 mg, 0.96 mmol) in N,N-dimethylformamide (5 ml) was added potassium carbonate (396 mg, 2.87 mmol) and benzyl bromide (0.25 ml, 2.10 mmol). The mixture was stirred at room temperature for 72 hours. Water (10 ml) and ethyl acetate (20 ml) was added and the organic layer was separated, washed with water (3×10 ml), dried (MgSO4) and the solvent removed in vacuo. Purified by SP4 (20-50% ethyl acetate/hexane) to yield the title compound as an oil. 305 mg.

1. customthe organic layer was separated
2. washwashed with water (3×10 ml)
3. dry with materialdried (MgSO4)
4. customthe solvent removed in vacuo
5. customPurified by SP4 (20-50% ethyl acetate/hexane)